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下血清与严重COVID-19的死亡率有关:随机试验的二次分析

Mario H Vargas¹, Jaime Chávez², Rosangela Del-Razo-Rodríguez³

¹Departamento de Investigación en Hiperreactividad Bronquial, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, CP 14080, Mexico City, Mexico. mhvargasb@yahoo.com.mx.

Biological trace element research

|April 15, 2025

概括

在急诊室到达时血清水平较低,与严重的COVID-19患者死亡风险较高有关. 在住院期间,水平倾向于下降,无论患者的生存情况如何.

科学领域:

* 临床医学临床医学
* 传染病传染病
* * 关键护理的关键护理

背景情况:

* 严重的冠状病毒病 (COVID-19) 与许多实验室异常有关.
*区分真正的死亡风险因素与器官功能障碍指标至关重要.
*之前的研究已经描述了严重的COVID-19中各种实验室测试异常.

研究的目的:

* 调查初始和时间平均实验室检测结果和血清细胞因子与严重COVID-19死亡率之间的关联.
* 确定特定的实验室标记物,预测住院COVID-19患者的致命结果.

主要方法:

* 临床试验的二次分析 (ClinicalTrials.gov No. NCT04443673) 涉及56名严重的COVID-19患者.
*分析初始实验室测量和住院期间所有测量的加权平均值.
* 使用单变量和多变量逻辑回归来评估与死亡率的关联.

主要成果:

*初始平均体积 (MCV) 和血清水平与死亡率有关.
*在多变量分析中,MCV (OR 1.253) 和 (OR 0.091) 仍然是死亡的重要预测因素.
*与幸存者相比,非幸存者对尿素,BUN,中性粒细胞,IL-6,IL-10的加权平均值更高,对白蛋白,淋巴细胞和单细胞的水平更低.

结论:

* 较低的初始血清水平是严重的COVID-19中死亡的重要风险因素.
* 血清水平在住院期间倾向于下降,无论患者的结果如何.
* 特定的炎症标志物和血液学参数在未幸存者中升高.

关键词:

在 COVID-19 疫情中,炎症炎症是一种炎症.是的重要组成部分.平均体质体积的体积.风险因素风险因素风险因素

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