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一种基于MIP技术的新型电化学传感器,用于敏感地测定平板剂形式和血清样本中的cinacalcet化物

Ipek Kucuk^1,2, Selenay Sadak^2,3, Selda Zengin Kurnalı⁴

¹Department of Analytical Chemistry, Faculty of Pharmacy, Başkent University, 06790, Ankara, Türkiye.

Mikrochimica acta

|April 15, 2025

概括

开发了一种新的分子印记聚合物传感器,用于检测超血症药物Cinacalcet化 (CIN). 这种高度灵敏的CIN@MIP/GCE传感器准确地测量了制药和生物样本中的CIN.

科学领域:

电化学电化学电化学
材料科学材料科学材料科学
分析化学分析化学

背景情况:

酸 (CIN) 对于管理高血症至关重要.
准确和灵敏地检测CIN对于治疗疗效和患者安全至关重要.
现有的检测方法可能缺乏复杂矩阵所需的灵敏度或选择性.

研究的目的:

开发一种高灵敏性和选择性的基于分子印记聚合物 (MIP) 的电化学传感器,用于化 (CIN).
为了优化CIN@MIP/GCE传感器的制造和检测参数.
使用现实世界样本验证传感器的性能,包括药物配方和人体血清.

主要方法:

在玻璃碳电极 (GCE) 上在CIN的存在下对o-phenylenediamine (o-PD) 的电聚合,以创建一个MIP传感器 (CIN@MIP/GCE).
使用原子力显微镜 (AFM) 和扫描电子显微镜 (SEM) 进行表面表征.
使用循环电压测量 (CV),电化学阻抗光谱 (EIS) 和微分脉冲电压测量 (DPV) 的电化学表征和性能评估.

主要成果:

优化的CIN@MIP/GCE传感器在其表面显示了特定的分子印记 (空隙),由AFM证实.
传感器表现出卓越的分析性能,探测极限低 (LOD) 为0.17 × 10−12 M,线性范围广.
高恢复率 (100.19%在药片中,101.82%在血清中) 和对干扰物质的选择性证实了传感器的可靠性和特异性.

结论:

开发的CIN@MIP/GCE传感器提供了一个高度敏感,选择性和可靠的平台,用于电化学检测cinacalcet化.
这种基于MIP的传感器显示出药品分析和治疗药物监测质量控制的巨大潜力.
该研究强调了分子印记技术在为制药化合物制造量身定制的电化学传感器方面的有效性.

关键词:

锡纳酸化酸微分脉冲电压测量微分脉冲电压测量电化学传感器是一种电化学传感器.打印因素是一个打印因素.经过修改的玻璃碳电极有分子印记的聚合物.制药剂量形式制药剂量形式

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