微生物群肠-大脑轴:对大脑发育和心理健康的影响
Yasmin N Ramadan1, Saleh F Alqifari2, Khaled Alshehri3
1Department of Microbiology and Immunology, Faculty of Pharmacy, Assiut University, Assiut, 71515, Egypt. yasmine_mohamed@pharm.aun.edu.eg.
Molecular neurobiology
|April 15, 2025
概括
肠道微生物群通过双向途径影响大脑健康和功能. 了解微生物组-肠-大脑轴是管理神经和胃肠道疾病的关键.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群,包括数万亿个微生物,显著影响宿主健康和疾病.
- 在肠道和中枢神经系统 (CNS) 之间存在双向通信通道.
- 肠道微生物组的平衡对于正常的大脑功能和情绪调节至关重要,而中枢神经系统控制胃肠道生理学.
研究的目的:
- 阐明微生物组-肠道-大脑轴内的复杂相互作用.
- 突出肠道微生物群在早期大脑发育中的作用.
- 深入了解微生物组介导疾病和潜在的管理策略.
主要方法:
- 本综述综合了关于微生物组-肠-大脑轴的现有研究.
- 它研究了肠道微生物群对神经和胃肠道健康的影响.
- 该审查探讨了中枢神经系统调节对肠道功能的影响.
主要成果:
- 微生物组-肠-大脑轴的干扰与神经系统和胃肠道疾病有关.
- 肠道微生物组在大脑发育阶段起着至关重要的作用.
- 肠道微生物群的不平衡会导致或加剧病理状况.
结论:
- 重新平衡肠道微生物组为各种疾病提供了潜在的治疗途径.
- 对微生物组-肠-大脑轴的进一步研究对于开发有针对性的干预措施至关重要.
- 保持健康的肠道微生物群对于整体的神经和胃肠道健康至关重要.
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