在不受控制的慢性鼻炎中,明显的炎症模式和鼻腔细菌失生症
Yunfan Zhang1,2, Zheng Liu3, Fan Yuan4,5
1Department of Otolaryngology, Peking University Third Hospital, Haidian District, No. 49 Huayuan North Road, Beijing, 100191, People's Republic of China.
概括
无法控制的慢性鼻炎 (CRS) 与明显的炎症标志物和鼻腔细菌失生症有关. 这些发现提供了对不受控制的CRS和潜在的诊断方法的病原体的见解.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 慢性鼻炎 (CRS) 的管理强调疾病控制.
- 乙酸性炎症是不受控制的CRS的关键风险因素.
- 鼻腔细菌失生症涉及到eosinophilic CRS病原体,但其在疾病控制中的作用尚未被探索.
研究的目的:
- 为了研究不受控制的CRS的炎症模式.
- 为了探索鼻腔细菌失生症在不受控制的CRS患者.
- 确定CRS中炎症,失生症和疾病控制之间的关联.
主要方法:
- 对48名不受控制的CRS,44名受控制的CRS和58名健康个体进行了横截面研究.
- 鼻子粘液和外周血液的炎症内型分析.
- 16S rRNA基因测序以描述鼻腔细菌微生物群.
主要成果:
- 没有控制的CRS患者表现出粘液中异氨基酸衍生神经毒素 (EDN),血液异氨基酸,基氨基酸和淋巴细胞的升高.
- 鼻子粘液EDN是不受控制的CRS最强的预测因子 (AUC=0.798).
- 在不受控制的CRS中发现了明显的细菌失生症,微生物组模型实现了高诊断准确性 (AUC=0.949),由乙酸和基酸计数 (AUC=0.974) 增强.
结论:
- 失控的CRS的特点是独特的局部和全身炎症概况.
- 在不受控制的CRS中存在显著的细菌失生症.
- 这些发现揭示了不受控制的CRS的致病性,并表明了疾病状况的潜在生物标志物.
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