孕产妇的血栓友爱会破坏胎儿的逆氧化和静止
Natasa Z Djordjevic1, Tanja R Novakovic2, Zana C Dolicanin3
1Department of Natural and Mathematical Sciences, State University of Novi Pazar, Vuka Karadzica 9, Novi Pazar, 36300, Serbia. natasadj@np.ac.rs.
Reproductive sciences (Thousand Oaks, Calif.)
|April 15, 2025
概括
怀孕期间的母体血栓友显著影响胎儿的发育. 暴露于血栓友爱症的婴儿经历了增加的氧化应激,由增加的有害分子和耗尽的保护性抗氧化剂表明.
科学领域:
- 产科和妇科 产科和妇科
- 围产儿医学 围产儿医学
- 生物化学 生物化学
背景情况:
- 胎儿的氧化还原稳定对于正常的产前发育至关重要.
- 孕产妇血栓形成症是一种可能影响怀孕结果的疾病.
- 了解血栓友对胎儿发育的影响至关重要.
研究的目的:
- 为了研究母体血栓友对胎儿氧化还原平衡的影响.
- 在怀孕第二季度评估羊水细胞和羊水的氧化还原特征.
- 为了识别由血栓友改变的特定氧化还原生物标志物.
主要方法:
- 检测了包括超氧化 (O2.-),过氧化 (H2O2),氧化 (NO),过氧化 (ONOO-),脂类过氧化 (LPO),微核,减少的谷 (GSH) 和氧化谷 (GSSG) 在内的氧化生物标志物的度.
- 分析了怀孕16-18周之间的健康孕妇和患有血栓友爱症的孕妇的胎液细胞和胎液.
- 在两个组之间比较了氧化还原概况.
主要成果:
- 患有血栓形成症的孕妇在羊水细胞中显示出明显更高的O2,NO,ONOO和LPO度.
- 在患有血栓友爱的母亲的羊水细胞中观察到较低的H2O2,GSH和GSSG度.
- 血栓友群的羊水中发现了高GSSG水平,而其他羊水生物标志物没有显著差异.
结论:
- 怀孕第二个三个月的母体血栓形成导致胎儿的强烈氧化应激.
- 这种氧化应激的特点是过度生产反应性氧和物种 (O2.-, NO, ONOO-, LPO).
- 这些发现凸显了血栓友对胎儿氧化还原平衡的有害影响,并表明了对胎儿发育的潜在影响.
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