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Updated: May 13, 2025

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
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工程细胞间通信使用M13菌体和基于CRISPR的基因调节用于Escherichia coli中的多细胞计算

Hadiastri Kusumawardhani1, Florian Zoppi2, Roberto Avendaño2

  • 1Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. hadiastri.kusumawardhani@unil.ch.

Nature communications
|April 15, 2025
PubMed
概括

研究人员开发了用于细菌通信的新合成生物学工具,使多细胞计算成为可能. 该系统使用CRISPR指导RNA的基介导转移用于工程化大肠杆菌联盟中的敏感,可编程逻辑门.

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相关概念视频

CRISPR and crRNAs02:53

CRISPR and crRNAs

Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
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