动脉动中的生物标志物和认知衰退:一项前性队列研究
Philipp Krisai1, Magdalena Eberl2, Michael Coslovsky1
1Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
Scientific reports
|April 15, 2025
概括
像GDF-15,cystatin C和hs-TnT这样的生物标志物与心房患者的认知能力下降有关. 这表明炎症和神经元损伤可能会导致AF的认知障碍,即使使用抗凝药.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 生物标志物研究 生物标志物研究
背景情况:
- 心房动 (AF) 与认知能力下降的风险增加有关.
- 了解潜在的机制对于制定预防策略至关重要.
- 之前的研究已经探索了各种因素,但需要对AF患者进行全面的生物标志物分析.
研究的目的:
- 调查一组广泛的生物标志物与心房动患者认知衰退之间的关联.
- 确定潜在的非缺血性机制,有助于这一群体的认知障碍.
- 使用已识别的生物标志物开发认知衰退的预测模型.
主要方法:
- 1440名AF患者接受了基线生物标志物数据和认知评估 (蒙特利尔认知评估 - MoCA).
- 认知能力下降被评估在平均4年的随访期间.
- 统变逻辑回归,LASSO回归和联合预测模型被用于分析生物标志物协会.
主要成果:
- 6.5%的AF患者在4年内经历认知衰退,尽管抗凝率高.
- 与认知衰退相关的关键生物标志物包括GDF-15,cystatin C和高灵敏度的Troponin T (hs-TnT).
- 结合了多种生物标志物 (IGFBP-7,GDF-15,Cystatin C,hsCRP,ALAT,GFAP,ESM-1,FGF23) 的组合模型,实现了预测认知衰退的AUC为0.73.
结论:
- 认知能力下降发生在显著比例的AF患者中,无论抗凝血状态如何.
- 与炎症,神经元损伤和潜在的粉样β途径相关的生物标志物与AF的认知衰退有关.
- 这些发现突出了潜在的非缺血性机制,有助于AF患者的认知障碍.
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