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Updated: Jul 12, 2026

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice
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质母细胞瘤异质性和可塑性的相关调节影响图

Chloé Bernhard1, Konstantinos Geles2, Geoffrey Pawlak2

  • 1UMR7021 CNRS, University of Strasbourg, Illkirch, France.

NPJ precision oncology
|April 15, 2025
PubMed
概括

我们开发了GBM-cRegMap,这是一个在线工具,将质母细胞瘤 (GBM) 瘤数据映射到同调节网络. 这种资源完善了GBM分类,识别了NKX2.5等关键调节剂,并揭示了化疗下瘤的可塑性.

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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