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肠道微生物群和代谢物的对近视和病态近视的因果关系影响:一个调解的门德尔随机化研究
Jingwen Hui1,2,3, Kexin Tang1,2,3, Yuejun Zhou1,2,4
1Tianjin Eye Hospital, No.4 Gansu Road, Heping District, Tianjin, 300020, China.
Scientific reports
|April 15, 2025
概括
肠道微生物及其代谢物在近视的发展中起着因果作用. 脂质代谢物调解了这种肠眼轴,为近视的进展提供了潜在的治疗点.
科学领域:
- 眼科医生 眼科 眼科
- 微生物学 微生物学
- 遗传学 是一个遗传学.
背景情况:
- 近视是导致视力障碍的主要原因,影响全球人口的很大一部分.
- 虽然遗传学和环境是已知的因素,但肠道微生物群在近视症中的作用是新兴的研究领域.
- 肠道微生物群通过代谢相互作用影响宿主生理,可能影响眼睛健康.
研究的目的:
- 使用孟德尔随机化 (MR) 方法调查肠道微生物群,代谢物和近视和病态近视 (PM) 风险之间的因果关系.
- 为了确定特定的肠道微生物种群和与近视相关的代谢物.
- 探索代谢物在肠道微生物群与近视相关性中的调解作用.
主要方法:
- 使用孟德尔随机化 (MR) 方法,将遗传变异作为工具变量.
- 分析了来自473种肠道微生物种群和233种代谢物的大型全基因组关联研究 (GWAS) 的数据.
- 评估对近视和病态近视 (PM) 风险的因果影响.
主要成果:
- 确定了特定的肠道微生物种群和代谢物,与近视和PM有显著的因果关系.
- 发现脂质代谢物调解肠道微生物群对近视发展的影响.
- 观察到显著的调解效应,表明代谢物是潜在的治疗点.
结论:
- 肠道微生物群和特定的代谢物与近视和病态近视 (PM) 有因果关系.
- 脂质代谢物调解肠道微生物群对近视的影响,突出显示肠道代谢物-眼睛轴.
- 研究结果表明,通过向肠道微生物群,可以通过新的治疗策略来预防和治疗近视.
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