由HFD诱导的LPS转位和血脂升高加剧了过敏性鼻炎的炎症反应
Shaopeng Peng1, Xuyang Cai1, Jing Tang1
1Department of Pharmacy, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Scientific reports
|April 15, 2025
概括
高脂肪饮食 (HFD) 通过破坏肠道屏障,增加诸如脂多糖 (LPS) 和脂质等炎症触发物,并激活关键炎症通路,使过敏性鼻炎 (AR) 恶化.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 过敏性鼻炎 (AR) 是一种广泛的慢性疾病.
- 高脂肪饮食 (HFD) 越来越多地与增加对AR的敏感性有关.
- 了解连接饮食和AR的机制对于公共健康至关重要.
研究的目的:
- 在大鼠模型中研究HFD对卵蛋白 (OVA) 诱导的AR的影响.
- 探索HFD对肠道屏障完整性,全身炎症和关键分子通路的影响.
- 通过体外巨模型验证发现.
主要方法:
- 利用一种对OVA敏感的AR老鼠模型养一个HFD.
- 评估肠道屏障功能 (紧结蛋白),血清脂质和LPS水平,以及炎症标志物 (NLF,血清).
- 在组织中和体外使用用棕酸 (PA) 和LPS治疗的THP-1巨细胞检查NF-κB和NLRP3炎症酶激活.
主要成果:
- 在HFD养的AR大鼠中,紧结蛋白减少,血清脂质和LPS增加,鼻腔和血清样本炎症增加.
- 在HFD养的AR大鼠的鼻腔和结肠组织中,NF-κB和NLRP3炎症酶活性显著增强.
- 在体外,PA和LPS协同扩大了巨细胞的炎症反应,反映了体内发现.
结论:
- 由HFD引起的肠壁功能障碍促进LPS转移到血液中.
- 血清LPS和脂质升高通过NF-κB和NLRP3炎症酶激活加剧AR炎症.
- 针对肠道健康的饮食干预措施可能有利于管理过敏性鼻炎.
相关概念视频
02:06Allergic Reactions
27.2K
Overview
27.2K
01:38Inflammation
51.5K
Overview
51.5K
01:26Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K
01:30Hypersensitivities
391
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
391
01:20Asthma: Pathogenesis and Management
245
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
245