HER2-低表达的演变从原发性转移到配对的转移性胃癌病变
Wen-Zhuo He1, Yuan-Zhong Yang2, Chen-Xi Yin3
1Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, PR China.
NPJ precision oncology
|April 15, 2025
概括
在胃癌中HER2低表达是一种可操作的生物标志物. 这项研究发现,HER2状态可以从原发性瘤变为转移性瘤,这表明可能需要重新活检才能获得向治疗的资格.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 胃肠道癌症 胃肠道癌症
背景情况:
- 低HER2表达是胃癌中新兴的可操作生物标志物.
- 了解原发性和转移性瘤之间的HER2表达变化对于治疗至关重要.
- 关于胃癌进展中的HER2状态异调的数据有限.
研究的目的:
- 研究从原发性胃癌到转移性胃癌的HER2表达状态的变化.
- 确定HER2状态转换的频率和临床影响.
- 评估转移性胃癌中HER2评估再活检的必要性.
主要方法:
- 对332名转移性胃癌患者的回顾性分析.
- 在匹配的原发性和转移性瘤中评估HER2状态 (负,低,阳性).
- HER2状态转换与临床病理特征的相关性.
主要成果:
- 在很大一部分患者中观察到HER2状态转换.
- 在HER2-阴性原发性瘤中,32.7% (74/226) 在转移中转化为HER2-低.
- 转换为HER2-低与甲基慢性和非腹膜转移有关.
结论:
- 在原发性和转移性胃癌之间,HER2表达状态可以显著变化.
- 重复活检以评估转移性疾病中的HER2状态可能是必要的.
- 准确的HER2评估可能会扩大胃癌患者获得向HER2治疗的资格.
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