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在膀癌中循环瘤DNA和循环瘤细胞 - - 从发现到临床实施
Sia V Lindskrog1,2, Trine Strandgaard1,2, Iver Nordentoft1,2
1Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.
Nature reviews. Urology
|April 15, 2025
概括
使用循环瘤DNA (ctDNA) 和循环瘤细胞 (CTC) 的液体活检显示出对非侵入性膀癌监测的前景. 这些基于血液的生物标志物可以指导治疗和监测,有可能改变患者的护理.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 液体活检为癌症检测和监测提供了传统组织活检的非侵入性替代方案.
- 循环瘤DNA (ctDNA) 和循环瘤细胞 (CTC) 正在成为瘤学的关键血基生物标志物.
- 膀癌管理可以从先进的诊断工具中受益,以提供个性化的患者护理.
研究的目的:
- 审查ctDNA和CTCs作为膀癌中的生物标志物的临床潜力.
- 探索液体活检在预后,治疗监测和复发的早期检测中的应用.
- 评估ctDNA和CTCs对膀癌患者管理的变革性影响,可能与尿瘤DNA分析相结合.
主要方法:
- 在膀癌中评估ctDNA和CTC的研究的文献综述.
- 对基于血液的生物标志物的疗效进行临床试验数据的分析.
- 关于液体活检在疾病检测,监测和复发监测中的作用的综合证据.
主要成果:
- ctDNA和CTCs在膀癌中显示出显著的临床潜力.
- 这些生物标志物对于预测和监测治疗反应是有效的.
- 早期检测最小残留疾病和复发是可以通过ctDNA和CTC分析.
结论:
- 液体活检,特别是ctDNA和CTC,在膀癌治疗中具有变革性的潜力.
- 将这些生物标志物纳入临床实践可以实现量身定制的治疗指导和优化监测.
- 在临床试验中进一步评估对于广泛采用和改善患者结果至关重要.
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