酸盐通过口腔微生物群改善酒精诱导的认知障碍
Xiangxue Li1, Zhaojun Ni1, Weixiong Shi2
1Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), No.51 Huayuan North Road, Haidian District, Beijing, 100191, China.
Journal of neuroinflammation
|April 15, 2025
概括
酸盐补充剂通过恢复口腔微生物群来减轻小鼠中酒精诱导的认知障碍和神经炎症. 这突出了影响大脑健康的"微生物群-口腔-大脑轴".
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 饮酒与认知缺陷和炎症有关.
- 口服酸盐可以通过调节口腔微生物群来改善衰老中的认知能力.
- 酸盐对与酒精有关的认知衰退和口腔微生物群的影响尚不清楚.
研究的目的:
- 研究酸盐对酒精引起的认知障碍的保护作用.
- 探索口腔微生物群在调解这些影响中的作用.
- 检查口腔微生物群,酸盐代谢和人类饮酒者的认知功能之间的关系.
主要方法:
- 给暴露于慢性酒精的小鼠服用酸盐补充剂.
- 评估认知功能,系统性和神经炎症.
- 通过无菌小鼠模型和便微生物移植研究了口腔微生物群的作用.
- 分析了人类饮酒者口腔微生物群组成和血中酸盐水平.
主要成果:
- 酸盐补充剂在小鼠中减少了酒精诱导的认知障碍,全身性和神经炎症.
- 酸盐恢复了酒精诱导的口腔微生物群失调.
- 酸盐的有益作用取决于口腔微生物群的存在.
- 从酸盐治疗的人类捐赠者的口腔微生物群移植改善了无菌小鼠的认知功能并减少了神经炎症.
- 在人类饮酒者中,较低的酸盐代谢细菌水平与较大的认知障碍和较低的血酸盐相关.
结论:
- 酸盐对酒精诱导的认知障碍和神经炎症具有保护作用.
- 口腔微生物群在调解酸盐的益处方面发挥着至关重要的作用.
- 一个小小的东西.
- 微生物群-口腔-大脑轴
- 涉及酸盐代谢可能会影响认知功能.
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