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路特里环胺减轻了风胺诱导的无氧能量消耗抑制
Matthew A Hadiono1, Alexis B Kazen1, Fatima A Aboulalazm1
1Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
肠道微生物组产生热量,影响能源消耗. 轮回环素 (RTC) 通过促进微生物能量生产来抵消体重增加,这表明它是一种潜在的肥胖治疗方法.
科学领域:
- 微生物学 微生物学
- 代谢过程中的代谢.
- 肠道微生物组研究研究
背景情况:
- 肠道微生物群落充当热生成生物质,影响宿主能量消耗.
- 肠道微生物群的组成会影响微生物的能量消耗,这种消耗可以通过像RISPERIDONE这样的异生菌来调节.
- 来自Limosilactobacillus reuteri*的代谢物RTC已经显示出对抗RISPERIDONE诱导的体重增加的潜力.
研究的目的:
- 研究RTC减轻RISPERIDONE诱导的体重增加的机制.
- 评估RTC对能量平衡和肠道微生物发酵的影响.
- 确定RTC是否可以积极调节无氧能量消耗.
主要方法:
- 在接受Risperidone,RTC或两者治疗的小鼠中进行综合能量平衡评估.
- 整体动物热量计用于测量能量消耗.
- 16S和便和便样本的全基因组猎枪测序,以分析微生物群体的组成和功能.
主要成果:
- 里斯比治疗抑制了无氧能量消耗 (EE),导致体重增加.
- 同时使用RTC改善了RISPERIDONE诱导的无氧EE抑制和体重增加.
- 瑞斯佩里和RTC治疗都改变了参与发酵的微生物种群的丰富性,特别是短链脂肪酸的生产.
结论:
- 轮回环素 (RTC) 可以通过增强肠道微生物发酵来积极调节无氧EE.
- RTC可能代表了一种新的治疗策略来控制肥胖.
- 肠道微生物组在热生成中的作用及其由细菌代谢物调节为代谢性疾病治疗提供了新的途径.
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