相关实验视频

Updated: May 13, 2025

Using the Overlay Assay to Qualitatively Measure Bacterial Production of and Sensitivity to Pneumococcal Bacteriocins

Using the Overlay Assay to Qualitatively Measure Bacterial Production of and Sensitivity to Pneumococcal Bacteriocins

Published on: September 30, 2014

青类A,一种未描述的类类,具有来自Penicillium herquei的细胞毒性

Mengyi Deng^1,2, Enrui Zhang^1,2, Fengtai Qiu^1,2

¹School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, P.R. China.

Natural product research

|April 16, 2025

概括

一种新型的sesterterpenoid,Penicinoid A,以及十种已知的化合物被从菌Penicillium herquei中分离出来. 这些化合物表现出显著的细胞毒性和中度的NO抑制活性.

科学领域:

自然产品化学自然产品化学
药理学药理学是指药理学的学科.
菌类学菌类学是指菌类学.

背景情况:

内生菌,如Penicillium herquei,是生物活性二次代谢产物的丰富来源.
Aconitum carmichaelii 含有多种内生菌微生物,具有潜在的制药应用.

研究的目的:

隔离和描述来自Penicillium herquei的二次代谢产物,这是Aconitum carmichaelii的内生植物.
评估分离的化合物的细胞毒性和抗炎性潜力.

主要方法:

使用NMR,HRESIMS和ECD计算进行结构阐明.
对A549,Hepg2,HeLa和HCT116癌细胞系进行细胞毒性查.
在LPS刺激的RAW 264.7巨细胞中抑制氧化 (NO) 生产.

主要成果:

确定了Penicinoid A,一种新的sesterterpenoid,以及十种已知的化合物.
化合物1-11表现出显著到微弱的细胞毒性作用 (IC50:1.537.3μM).
化合物1-11对NO生产表现出中度到弱的抑制活性 (IC50:10.935.1μM).

结论:

这项研究报告了首次从Penicillium herquei中分离出sesterterpenoids.
隔离的化合物具有显著的细胞毒性和抗炎性质,需要进一步研究.

关键词:

这种植物是Penicillium herquei.这种表达方式是Sesterterpenoid.它具有抗炎活性,具有抗炎活性.细胞毒性活动的细胞毒性.埃尔戈斯醇是一种活体固醇.

更多相关视频

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries

Published on: December 27, 2016

相关概念视频

Combined Effects of Drugs: Synergism

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...

Antimicrobial Proteins

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...