药物遗传检测在抑郁症治疗中的感知价值:混合方法来自PRIME护理研究的结果
Bonnie M Vest1, Laura O Wray1, Leland E Hull1
1Department of Family Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York-University at Buffalo (Vest), and U.S. Department of Veterans Affairs (VA) Center for Integrated Healthcare, VA Western New York Healthcare System, Buffalo (Vest, Wray); Division of General Internal Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston (Hull); Veterans Integrated Services Network (VISN) 4 Mental Illness Research, Education, and Clinical Center (MIRECC), Corporal Michael J. Crescenz VA Medical Center, and Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia (Lynch, Thase, Oslin); VISN 4 MIRECC, VA Pittsburgh Healthcare System, Pittsburgh (Chapman); VA Connecticut Healthcare System, West Haven, and Department of Nutritional Sciences, University of Texas at Austin, Austin (Ramsey); VA Rocky Mountain MIRECC for Suicide Prevention, and Division of Hospital Medicine, University of Colorado School of Medicine, Aurora (Simonetti).
医疗保健提供者报告说,在临床试验后,抑郁症治疗药物遗传学 (PGx) 测试的舒适度和感知价值增加. PGx测试可以提高患者的药物坚持.
科学领域:
- 药物基因组学 药物基因组学
- 临床精神病学 临床精神病学
- 医疗保健提供者教育教育
背景情况:
- 药物遗传学 (PGx) 测试提供了个性化抑郁症治疗的潜力.
- 提供者的观点对于将新型诊断工具纳入临床实践至关重要.
研究的目的:
- 探索医疗保健提供者对药物遗传学 (PGx) 测试在抑郁症治疗中的价值的看法.
- 评估参与实用性临床试验使用PGx测试后提供者态度的变化.
主要方法:
- 混合方法方法结合了调查和心理健康和初级保健提供者的定性访谈.
- 使用概括估计方程对前后调查数据 (N=217) 进行定量分析.
- 采访的定性分析 (N=61) 使用快速定性分析.
主要成果:
- 提供者报告说,他们对PGx测试的舒适性以及试验后证据基础的强度有所增加.
- 与初级保健提供者相比,精神卫生提供者表现出更高的同意水平.
- 定性数据揭示了对特定患者群体的感知价值以及改善患者购买药物的潜力.
结论:
- 医疗保健提供者通常对药物遗传测试在试验经验后在抑郁症护理中的实用性持积极看法.
- 提供者舒适度和对PGx测试在抑郁症治疗中的感知证据基础随着使用而改善.
- PGx测试可以成为增强患者参与抑郁症药物治疗的宝贵工具.
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