系统性免疫-炎症指数在评估疾病活动和原发性斯乔格伦综合征的外腺干扰中
Ozlem Kilic1, Mehmet Nur Kaya1, Duygu Tecer1
1Department of Rheumatology, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkiye.
概括
系统性免疫炎症指数 (SII) 能够有效预测原发性肖格伦综合征 (pSS) 的腺外参与和疾病活性. 这种经济的血液检测可以帮助监测患者的病情和潜在的并发症.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 主要Sjogren综合征 (pSS) 是一种全身性自身免疫性疾病.
- 腺外干扰和疾病活动显著影响患者的预后.
- 需要新的生物标志物来有效监测pSS.
研究的目的:
- 调查系统性免疫炎症指数 (SII) 的预测价值,以确定pSS中的腺外参与和疾病活性.
- 为了将SII与其他血液学指数比较,如NLR,MLR,PLR和PCT.
- 在评估疾病严重程度时评估SII的诊断性能.
主要方法:
- 一项涉及128名pSS患者和102名健康对照者的横截面研究.
- 计算SII,MLR,PCT,NLR和PLR的方法.
- 使用ESSDAI和ESSPRI评估疾病活动.
- 后勤回归和ROC曲线分析以确定预测因素和诊断性能.
主要成果:
- 与健康对照组相比,pSS患者的NLR,MLR,SII,PLR和PCT显著更高.
- 在中度至重度疾病活性 (ESSDAI) 的患者中,SII显着更高.
- 在疾病活动方面,SII表现出强大的诊断性能 (ESSDAI的AUC:0.930,ESSPRI的0.983) 并与肺部和神经系统的参与有关.
结论:
- 血液学指数,特别是SII,是评估pSS中的腺外参与和疾病活性的实用和经济工具.
- SII可以帮助临床医生监测疾病进展,并识别患有特定器官参与风险的患者.
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