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Updated: May 13, 2025

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用不同的方法对塔罗霍尔酸与胰岛素结合的表征,用于潜在的口服配方

Chang Sun1, Shuanghao Wang1,2, Huihui Li1,3

  • 1State Key Laboratory of Analytical Chemistry for Life Science, National and Local Joint Engineering Research Center of Biomedical Functional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Changzhou Institute of Innovation and Development, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, People's Republic of China.

Electrophoresis
|April 16, 2025
PubMed
概括

陶罗胆酸 (TCA) 与口服胰岛素 (INS) 形成复合体,增强其结构稳定性和尺寸. 这种结合机制有望改善糖尿病管理中的口服胰岛素吸收和生物可用性.

关键词:
毛细血管电泳 毛细血管电泳在这种情况下,胰岛素胰岛素.互动互动互动互动互动.质谱测量质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量陶罗胆酸是一种酸.

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Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
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