李古斯 (Ligusticum chuanxiong):一个化学,药理和临床审查
Yin Wang1,2, Liuyun Wu1,2, Hulin Wang1,2
1Department of Pharmacy, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Frontiers in pharmacology
|April 16, 2025
概括
传统中医药Ligusticum chuanxiong (CX) 显示出显著的抗炎和抗氧化作用,用于治疗心脑血管疾病 (CCVD). 研究强调其多样化的代谢物和治疗机制,支持其临床价值.
科学领域:
- 药理学 药理学是指药理学的学科.
- 植物化学 植物化学
- 传统中国医药 传统中国医药
背景情况:
- Ligusticum chuanxiong (CX) 是一种传统的中国植物药物.
- 它以其抗炎和抗氧化特性而闻名.
- CX广泛用于治疗心脑血管疾病 (CCVD).
研究的目的:
- 审查最近在Ligusticum chuanxiong (CX) 研究方面的进展.
- 总结其化学成分,药理作用和临床应用.
主要方法:
- 系统的文献搜索 (2014-2025年) 使用关键词,如"Chuanxiong"",中国传统医学"",化学成分"",代谢物"",CCVDs"和"药物效应".
- 搜索的数据库包括PubMed,科学网,谷歌学者和CNKI.
- 从PubChem获取的化学结构;从TCM数据库中获得的经典处方.
主要成果:
- 确定了100多种代谢物,分为9个类别.
- 关键化合物包括森基努诺利德A,ligustilide,四甲基pyrazine (TMP) 和CX多糖化物 (LCP).
- 通过抗血小板,内皮细胞保护,抗炎症,抗氧化和抗亡机制,CX在治疗CCVD (动脉样硬化,缺血-再输血损伤,高血压) 中表现出有效性.
结论:
- 对于多系统疾病,特别是CCVDs,CX具有显著的临床价值.
- 有证据支持它的治疗潜力.
- 建议进行进一步的研究,以充分探索其药用益处.
相关概念视频
01:27Effects of Chemicals: Overview
2.4K
Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable...
2.4K
01:11Direct-Acting Cholinergic Agonists: Therapeutic Uses
1.9K
Direct-acting cholinergic agonists have many therapeutic uses in various medical fields. Choline esters, including acetylcholine, have limited clinical utility due to their non-selectivity and short duration of action. Still, acetylcholine and carbachol are applied topically during ophthalmologic surgery to induce miosis. Pilocarpine, a muscarinic and ganglionic stimulator, effectively treats open-angle glaucoma and alleviates xerostomia and dry mouth caused by radiotherapy or Sjögren...
1.9K
01:29Cholinergic Antagonists: Chemistry and Structure-Activity Relationship
3.2K
Cholinergic antagonists bind to cholinergic receptors and limit the effects of acetylcholine and other cholinergic agonists. Based on the specific cholinergic receptor affinity, these antagonists are classified as muscarinic or nicotinic. Anticholinergics interrupt parasympathetic innervations while sympathetic innervations remain uninterrupted. Muscarinic antagonists are also called 'muscarinic antagonists', 'antimuscarinics', or 'parasympatholytics'. Nicotinic...
3.2K
01:29Spasmolytic Agents: Chemical Classification
1.5K
Spasmolytic agents are drugs used to alleviate muscle spasms and spasticity. They can be categorized into different chemical groups based on their mechanisms of action. Centrally acting spasmolytics primarily affect the spinal cord, while others directly target skeletal muscle cells.
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also...
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also...
1.5K