适度升高的环境温度与透析患者的死亡率有关,但与移植患者的死亡率无关
Cécile Couchoud1, Thierry Lobbedez2, Sahar Bayat3
1REIN registry, Agence de la biomédecine, Saint Denis La plaine, France.
Clinical kidney journal
|April 16, 2025
概括
高温增加了透析患者的死亡风险,但不增加移植患者的死亡风险. 这项研究强调了热浪期间透析患者的脆弱性,强调了有针对性的公共卫生干预措施的必要性.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學專業.
- 公共卫生 公共卫生
背景情况:
- 热浪与一般人口死亡率的增加有关.
- 有限的研究存在于移植和透析患者的高温影响.
- 这项研究解决了慢性病 (CKD) 第五阶段患者的热暴露和死亡率方面的知识差距.
研究的目的:
- 调查法国CKD5期患者高温与死亡率之间的关联.
- 分析透析患者与移植患者之间的风险.
- 探索高温暴露的各种定义.
主要方法:
- 追溯队列研究分析了法国REIN注册表 (2012-2022) 的数据.
- 用于评估温度指标与死亡率之间的关联的Poisson模型,控制时间趋势,季节性和混因素.
- 基于每小时和每天的测量,探索多个升温定义.
主要成果:
- 超过32.5°C的最高温度与透析患者死亡率的增加显著相关 (发生率:1.09,95% CI:1.04-1.15).
- 在移植接受者中,高温和死亡率之间没有显著的关联.
- 在研究期间,116,808名透析患者中发生了超过2万例死亡,在64,531名移植患者中发生了超过3300例死亡.
结论:
- 高温对透析患者来说是一个显著的死亡风险.
- 与透析患者相比,移植接受者对高温的脆弱性似乎较小.
- 需要进一步的研究来了解热的生物影响及其与其他环境因素的相互作用.
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