患有甲状腺结节与甲状腺癌的患者的焦虑障碍:一项回顾性队列研究
Edy Kornelius1,2, Shih-Chang Lo2, Chien-Ning Huang1,2,3
1School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Frontiers in endocrinology
|April 16, 2025
概括
甲状腺结节与更高的焦虑风险有关,但与甲状腺癌相比,抑郁症和失眠的风险较低. 这一发现突出了癌症担忧之外的结节的心理负担.
科学领域:
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 甲状腺结节很常见,通常需要监测,可能会导致心理困扰.
- 甲状腺结节的心理影响尚不清楚.
- 偶然发现的甲状腺结节需要进一步调查它们对患者的影响.
研究的目的:
- 研究甲状腺结节与心理健康结果之间的关联.
- 为了比较患有甲状腺结节与甲状腺癌的患者焦虑,抑郁,情绪障碍和失眠的风险.
- 评估甲状腺结节的心理影响,而不依赖于癌症诊断.
主要方法:
- 使用TrinetX数据 (2010-2023) 的回顾性队列研究,涉及1.18亿名患者.
- 倾向性得分匹配被用来比较患有甲状腺结节的患者与患有甲状腺癌的患者.
- 主要结局是焦虑症风险;次要结局包括抑郁症,情绪障碍和失眠.
主要成果:
- 分析了138,803个匹配对的队列 (甲状腺结节与甲状腺癌).
- 患有甲状腺结节的患者患有焦虑症的风险显著增加 (HR 1.06).
- 与甲状腺癌患者相比,甲状腺结节患者患抑郁症,情绪障碍和失眠的风险较低.
结论:
- 甲状腺结节与焦虑的风险增加有关.
- 甲状腺结节的心理影响,特别是焦虑,需要进一步调查.
- 结节患者的焦虑风险增加,即使与普通人群相比,仍然存在,这表明除了癌症之外还有其他因素.
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