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在鼻癌患者的放射治疗期间,T细胞子集的线粒体功能变化

Quan Wang¹, Xiangzhi Yin², Hongbo Liu¹

¹Department of Radiation Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266035, P.R. China.

Oncology letters

|April 16, 2025

概括

放射治疗 (RT) 影响鼻癌 (NPC) 患者的免疫细胞,减少淋巴细胞,但增加记忆T细胞. 线粒体膜潜力在CD4+T细胞和淋巴细胞数量中预测RT疗效.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
线粒体生物学线粒体生物学

背景情况:

在T细胞中的线粒体功能障碍与瘤治疗结果有关.
放射治疗 (RT) 对外围免疫细胞线粒体功能的具体影响尚不清楚.
了解这些变化对于优化癌症治疗策略至关重要.

研究的目的:

研究鼻癌 (NPC) 患者的免疫细胞中线粒体质量 (MM) 和线粒体膜潜力 (MMP) 的动态变化,这些患者接受了RT.
评估这些线粒体指标与RT疗效之间的相关性.
确定潜在的生物标志物来预测NPC中的RT反应.

主要方法:

在RT之前,期间和之后,从局部晚期NPC患者收集了外周血液样本.
使用流细胞计和免疫光技术来测量淋巴细胞子集,MM和低MMP (MMPlow).
单变量和多变量逻辑回归,以及ROC曲线分析,用于评估临床因素和预测值.

主要成果:

RT导致淋巴细胞数量和CD4+T细胞比例下降,但增加了CD4+和CD8+记忆效应T (Tem) 细胞.
在CD4+效应T (Te) 细胞中,MMPlow显著下降,而MM没有显著变化.
CD4+Te细胞中的淋巴细胞数和MMPlow被确定为RT临床疗效的独立预测因子 (AUC=0.89组合).

结论:

放射治疗可以抑制外围免疫细胞,但也可以激活记忆T细胞子集并增强CD4+Te细胞线粒体功能.
线粒体功能指标,特别是CD4+T细胞中的MMPlow,以及淋巴细胞计数,是NPC中RT疗效的有价值预测指标.
监测免疫细胞线粒体状态可以指导NPC患者的个性化治疗方法.

关键词:

在CD4+ T细胞中,有CD4+ T细胞.在 CD8+ T 细胞中.在局部发达的鼻癌.线粒体功能障碍线粒体功能障碍辐射疗法辐射疗法

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