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Updated: May 15, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
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在Wistar大鼠中多代暴露于DDT残留物微量度:对生物识别发育和生物化学参数的影响

Fernanda Coleraus1,2,3, Camilla de Marchi Sanches Azevedo3, Jaine Luana Pavlak1

  • 1Laboratory of Cellular Toxicology, Center for Medical and Pharmaceutical Sciences, State University of Western Parana (Unioeste), Cascavel, Parana 85819110, Brazil.

Toxicology reports
|April 16, 2025
PubMed
概括

有机农药残留物,二二二乙烯 (DDD) 和二二二乙烯 (DDE),影响肝脏,脏,大脑和脂肪组织,特别是在几代雌性大鼠中. 影响取决于暴露组,年龄和性别.

关键词:
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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...