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桑托西 (Zanthoxylum rhoifolium) 兰的治疗和杀虫作用

Juliana Correa-Barbosa^1,2, Heliton Patrick Cordovil Brígido^3,4, Bibiana Franzen Matte⁵

¹Postgraduate Pharmaceutical Innovation Program, Institute of Health Sciences - Federal University of Pará (UFPA) Belém, Brazil.

Frontiers in chemistry

|April 16, 2025

概括

桑托西 (Zanthoxylum rhoifolium) 呈现出显著的抗莱什马尼亚活性和对莱什马尼亚寄生虫的选择性. 它的中性分数 (FN) 显示出有前途的治疗潜力和细胞增殖的增加.

科学领域:

药理学和天然产品化学药理学和天然产品化学
寄生虫学和热带医学
细胞生物学和伤口愈合

背景情况:

桑托西 (Zanthoxylum rhoifolium) 传统上被用作一种抗寄生虫剂.
Z. rhoifolium的植物化学特征和生物活动需要全面评估.
莱什马尼亚亚马逊菌是一种被忽视的热带疾病 - - 莱什马尼亚病的致病剂.

研究的目的:

为了研究Zanthoxylum rhoifolium的植物化学成分.
为了评估Z. rhoifolium提取物和分离物的抗莱什曼的活性.
评估Z. rhoifolium的细胞毒性和伤口愈合潜力.

主要方法:

乙醇提取物 (EE) 制剂,然后进行酸分离,以获得中性 (FN) 和类 (FA) 分数.
染色学分析和核磁共振用于物质识别 (切利利林分离).
在体外抗莱什曼菌对莱什曼菌亚马逊菌的测定 amazonensis促进性菌和阿马斯蒂哥特.
使用J774和VERO细胞系进行细胞毒性评估.
细胞增殖 (SRB测定) 和伤口愈合测定.

主要成果:

从中性分数 (FN) 中分离了切莱里思林.
在EE,FN和FA中,对Leishmania amazonensis promastigotes.表现出活性.
EE和FN表现出剂量依赖的菌感染抑制.
在VERO细胞中,FN没有表现出细胞毒性,而在J774细胞中表现出中度细胞毒性.
EE和FN增强了细胞增殖,FN促进了伤口愈合.

结论:

桑托西 (Zanthoxylum rhoifolium) 具有显著的抗莱什曼病毒活性和对寄生虫的高选择性.
中性分数 (FN) 显示了伤口愈合应用的潜力.
进一步研究Z. rhoifolium的治疗潜力是有必要的.

关键词:

莱什曼亚亚马逊人种 (Leishmania amazonensis) 是一个亚马逊人种.黄叶植物 (Rutaceae) 是一个植物.桑托西 (Zanthoxylum rhoifolium) 是一种的植物.类化合物是一种类化合物.细胞毒性细胞毒性

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