在结直肠癌查中,与错误的便免疫化学测试结果相关的因素
Shu-Yuan Wang1, Xue-Tao Dong2, Zhen Yuan1
1School of Medicine, Nankai University, Tianjin 300071, China.
World journal of gastrointestinal oncology
|April 16, 2025
概括
某些子组可能会收到不准确的便免疫化学测试 (FIT) 结果. 年龄,性别和生活方式等因素会影响假阳性和假阴性,影响结肠直肠癌查的准确性.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 预防医学 预防医学
背景情况:
- 便免疫化学测试 (FIT) 是一种常见的结直肠癌查工具.
- 关于影响虚假阳性/负性FIT结果的因素的证据有限.
- 现有研究对特定人群的FIT准确性提出了相互矛盾的数据.
研究的目的:
- 确定与假阳性和假阴性FIT结果相关的人口,生活方式和临床因素.
- 在大规模查计划中增强对FIT绩效的理解.
主要方法:
- 对天津结肠直肠癌查计划 (2012-2020年) 的4129947名参与者的回顾性分析.
- 包括24,890名无症状的个人,他们完成了FIT和结肠镜检查.
- 使用多变量物流回归来确定与不准确的FIT结果相关的因素.
主要成果:
- 年龄较大,女性性别,吸烟,饮酒,BMI较高和都增加了假阳性FIT的几率.
- 这些因素也降低了假负FIT的几率.
- 先进的腺瘤特征和癌症的存在降低了虚假阴性几率,而不规则的运动和分流器增加了虚假阳性几率.
结论:
- 在特定的子组中,FIT准确性可能会受到损害.
- 研究结果支持基于已识别的风险因素,个性化结直肠癌查策略.
- 进一步的研究可以完善FIT解释和查协议.
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