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Updated: May 13, 2025

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
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皮质表达在循环瘤细胞中持续存在,因为乳腺癌对抗体药物结合物产生抵抗力

Avanish Mishra, Rachel Abelman, Quinn Cunneely

    bioRxiv : the preprint server for biology
    |April 16, 2025
    PubMed
    概括

    抗体-药物合物 (ADCs) 在转移性乳腺癌中显示出有效性. 循环瘤细胞 (CTC) 的下降预测了反应,并且表皮质下调并不是TROP2或HER2ADCs的常见抵抗机制.

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