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Updated: May 13, 2025

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
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Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging

Published on: April 28, 2021

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通过交换RPA与Rad51消除了PCNA环绕的原料/模板连接点:对人类DNA损伤耐受路径之间的相互作用的影响

Jessica L Norris, Lindsey O Rogers, Grace Young

    bioRxiv : the preprint server for biology
    |April 16, 2025
    PubMed
    概括

    对于基因组的稳定性至关重要的是DNA损伤耐受性 (DDT) 路径,包括转化DNA合成 (TLS),模板切换 (TS) 和同质依赖重组 (HDR). 我们的研究揭示了同质依赖重组 (HDR) 激活如何导致PCNA的卸载,影响其他DDT通路.

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