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Updated: May 13, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

Published on: July 17, 2020

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通过与PPAT相互作用,NUDT5调节胺代谢和胺敏感性

Zheng Wu, Phong T Nguyen, Varun Sondhi

    bioRxiv : the preprint server for biology
    |April 16, 2025
    PubMed
    概括

    努迪克斯酸酶5 (NUDT5) 调节氨酸合成平衡. 它与PPAT的相互作用控制了新的 purin生物合成 (DNPB) 并影响了 thiopurine 药物疗效,提供了新的治疗点.

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