遗传风险与坚持"停止高血压的饮食方法"饮食之间的关联对于发展静脉血栓栓塞的疾病
Si Li1, Minghui Jiang1, Yunlong Guan1
1Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Research and practice in thrombosis and haemostasis
|April 16, 2025
概括
坚持饮食方法来阻止高血压 (DASH) 饮食降低了静脉血栓栓塞 (VTE) 的风险,即使对于那些具有高遗传倾向的人来说也是如此. 这种饮食模式提供了显著的保护,特别是在男性中,强调了个性化的VTE预防方法.
科学领域:
- 心血管健康 心血管健康
- 营养流行病学 营养流行病学
- 遗传学和疾病风险
背景情况:
- 饮食习惯和静脉血栓栓塞 (VTE) 风险之间的相互作用尚未完全理解.
- 饮食模式和遗传敏感性对VTE发展的综合影响需要进一步研究.
研究的目的:
- 检查坚持"停止高血压的饮食方法" (DASH) 饮食和多基因风险评分 (PRS) 对静脉瘤风险的独立和综合影响.
主要方法:
- 利用了来自411,539名参与者的英国生物库数据.
- 从食品频率调查问卷计算了DASH分数,并使用PRS计算了定量基因风险.
- 采用Cox的比例危险模型来评估VTE危险比率和DASH饮食与遗传易感性之间的相互作用.
主要成果:
- 较高的DASH饮食坚持与降低VTE风险相关 (HR,0.87).
- 具有低DASH坚持和高遗传风险的个体表现出最高的VTE风险 (HR,2.78).
- 高的DASH分数在遗传敏感个体中减轻了静脉瘤风险 (HR,0.84),在男性中观察到更明显的保护作用.
结论:
- 达什饮食与静脉瘤风险降低有关,可以抵消遗传倾向.
- 坚持低达什饮食会增加静脉瘤风险,特别是在具有高遗传易感性的人群中.
- 整合饮食和遗传信息对于个性化的VTE预防策略至关重要,具有显著的性别特异性差异.
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