在提尔泽帕提德治疗后急性十二指肠 perforation:一个案例报告
Maho Hayashi1, Koji Hayashi2, Yusuke Tsujigiwa3
1Department of Internal Medicine, Fukui General Hospital, Fukui, JPN.
Cureus
|April 16, 2025
概括
提尔泽帕提德可能会增加十二指甲孔穿孔的风险,特别是在未被诊断出Helicobacter pylori感染的患者中. 在使用这种药物时,仔细监测胃肠道症状至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 2型糖尿病 (T2DM) 的管理通常涉及克林仿制剂.
- 塞马格卢提德和蒂尔泽帕提德是用于T2DM和体重管理的葡萄糖类-1 (GLP-1) 和依赖葡萄糖的胰岛素聚 (GIP) 受体激动剂.
- 胃肠道不良事件是GLP-1受体激动剂的常见病例.
研究的目的:
- 报告一例罕见的急性十二指肠穿孔病例,该病例发生在接受泽帕提德治疗的患者身上.
- 为了调查tirezepatide使用和十二指肠穿孔之间的潜在关联.
- 为了强调Helicobacter pylori感染在与蒂尔泽帕提德相关的胃肠道并发症中的作用.
主要方法:
- 一个36岁的男性患有T2DM和先前死性带炎的病例报告.
- 审查患者的药物史,包括塞马格卢提德和蒂尔泽帕提德.
- 诊断成像 (揭示空气) 和紧急手术怀疑穿孔.
- 手术后的Helicobacter pylori检测和根除疗法.
主要成果:
- 患者在开始和增加蒂尔泽帕提德剂量后出现了严重的腹痛,恶心和吐.
- 诊断成像证实了急性十二指肠的穿孔.
- 手术后检测显示了Helicobacter pylori的感染.
- 患者在手术修复和H. pylori根除疗法后康复.
结论:
- 提尔泽帕提德可能与十二指甲孔穿孔的风险增加有关,特别是在同时患有未诊断的H. pylori感染的患者中.
- 接受提尔泽帕提德治疗的患者胃肠道症状恶化需要对潜在原因进行彻底调查,包括感染.
- 需要进一步的研究来阐明蒂尔泽帕提德诱导的胃肠道并发症的机制,并确定明确的危险因素.
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