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国家艾滋病药物援助计划对美国病毒抑制的贡献,2015-2022年

Kathleen A McManus¹, Amy Killelea¹, Erin Q Rogers¹

¹Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia.

medRxiv : the preprint server for health sciences

|April 16, 2025

概括

国家艾滋病药物援助计划 (ADAP) 在艾滋病毒感染者 (PWH) 中显著提高了病毒抑制率. ADAP客户实现了更高的病毒抑制,为整体公共卫生目标做出了重大贡献.

科学领域:

公共卫生公共卫生
艾滋病毒/艾滋病研究研究
医疗保健服务研究医疗服务研究

背景情况:

国家艾滋病药物援助计划 (ADAP) 对于为美国低收入人群提供艾滋病毒药物至关重要.
了解ADAP客户对整体病毒抑制 (VS) 的贡献对于公共卫生战略至关重要.
这项研究量化了ADAP对艾滋病病毒抑制率在艾滋病毒感染者 (PWH) 的影响.

研究的目的:

量化归因于国家艾滋病药物援助计划 (ADAPs) 客户的病毒抑制 (VS) 的比例.
为了比较ADAP客户和艾滋病毒感染者 (PWH) 的一般人群之间的病毒抑制率.
评估ADAP在实现国家艾滋病毒/艾滋病公共卫生目标方面的作用.

主要方法:

利用了公开可用的,从2015年到2022年的司法管辖区级数据.
分析了ADAP客户和更广泛的PWH人群的病毒载荷 (VL) 测试结果和VS数据.
计算了关于PWH与VL测试和VS的比例的描述性统计数据,具体确定了ADAP客户端贡献.

主要成果:

在ADAP客户中,病毒抑制 (VS) 率每年从81.2%到91.4%不等,明显高于一般PWH人群 (60-66.3%).
ADAP客户平均占PWH的23.1%,PWH的22.2%报告了VL,而PWH中30.8%的客户实现了VS.
尽管服务于不到25%的PWH,但ADAP客户占总病毒抑制率的近三分之一.

结论:

在艾滋病毒感染者 (PWH) 中,ADAP在实现病毒抑制方面发挥了不成比例的作用.
在ADAP客户中较高的VS率并不是由于那些报告病毒载量的人群中的过度代表.
尽管ADAP没有直接获得EHE资金,但其显著的影响值得考虑将其纳入联邦倡议,例如结束艾滋病毒流行 (EHE) 倡议.

关键词:

艾滋病药物援助项目艾滋病药物援助项目结束艾滋病毒流行病艾滋病病毒艾滋病病毒艾滋病病毒公共卫生计划公共卫生计划病毒抑制病毒抑制

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