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使用RNA测序数据预测无意中介的mRNA衰变从接事件在败血症使用RNA测序数据

Jaewook Shin1, Alger M Fredericks1, Brandon E Armstead1

  • 1Division of Surgical Research, Department of Surgery, Rhode Island Hospital/Alpert Medical School of Brown University; Providence, 02903, USA.

medRxiv : the preprint server for health sciences
|April 16, 2025
PubMed
概括

替代拼接和无意中介的mRNA衰变 (NMD) 是关键的基因表达调节者. 一个新的NMD管道揭示了在败血症中较高的NMD率,表明有目的的转录下调或改变拼接,并确定了潜在的败血症目标.

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