在二次渐进性多发性硬化中肌延伸:表型比较
Samuel Klistorner1,2, Michael H Barnett2,3,4, Chenyu Wang2,3
1Save Sight Institute, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
medRxiv : the preprint server for health sciences
|April 16, 2025
概括
在二次渐进性多发性硬化症 (SPMS) 中,胆管体体积显著增加,这表明正在进行的炎症并有可能作为疾病进展的生物标志物.
科学领域:
- 神经免疫学 神经免疫学
- 神经炎症是一种神经炎症.
- 生物标志物发现发现
背景情况:
- 冠状动脉 (CP) 与多发性硬化症 (MS) 的慢性炎症有关.
- 在早期MS中注意到CP扩大,但其在次级渐进性MS (SPMS) 中的作用仍然不清楚.
研究的目的:
- 在SPMS中量化CP体积.
- 在MS表型 (SPMS,RRMS,CIS) 中比较CP体积.
- 评估CP体积与疾病严重程度和进展的关联.
主要方法:
- 手动细分和规范CP体积. 手动细分和规范CP体积.
- 使用健康的对照队列进行年龄校正.
- 截面和纵向分析CP体积,心室体积,病变负担和大脑缩.
主要成果:
- 在SPMS患者中,CP量显著增加 (26%与CIS相比,17%与RRMS相比).
- 在SPMS中,CP扩大独立于心室大小.
- 在纵向分析中,CP体积与慢性病变扩张 (r2=0.31) 和脑体积损失 (r2=0.52) 有显著的相关性.
结论:
- 脑脊髓扩大是MS的渐进性特征,与心室扩张无关.
- 在SPMS中,CP扩大可能表明正在进行的炎症导致组织损伤.
- CP体积显示出作为MS进展的生物标志物的潜力.
更多相关视频
08:55Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
Published on: April 24, 2020
3.0K
04:25Author Spotlight: Bridging Gaps in Anatomy and Establishing a Foundation for Algorithmic Studies
Published on: December 15, 2023
2.1K
相关概念视频
01:19Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
01:25Secondary Spinal Cord Injury llI: Pathophysiology
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...