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Updated: Aug 27, 2026

Gene Transfer to the Developing Mouse Inner Ear by In Vivo Electroporation
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通过AAV介导的内耳基因传递触发了哺乳动物内耳的温和宿主免疫反应

Yasuko Ishibashi1,2, Jianliang Zhu1, Gwladys Gernoux3

  • 1Inner Ear Gene Therapy Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA.

Molecular therapy. Methods & clinical development
|April 16, 2025
PubMed
概括

腺相关病毒 (AAV) 基因疗法对听力损失有希望. 这项研究在AAV分娩后在小鼠内耳中发现了有限的宿主免疫反应,这表明临床翻译的潜力.

关键词:
在 EPLSpot 找 EPLSpot适应性免疫反应是一种适应性免疫反应.腺相关病毒的病毒.ddPCRR 在线播放基因治疗的基因疗法天生的免疫反应.内耳的内耳,就是内耳的内耳.中和抗体的抗体中和.有助于炎症的细胞因子.

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In-vitro Mutagenesis (Gene Knockouts)

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.