一种可注射的布洛芬持续释放复合水凝系统通过抗炎作用和血管生成有效地加速糖尿病伤口愈合
Zhibin Li1, Haijiang Dong1, Shenyu Yang2
1Department of Plastic and Aesthetic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People's Republic of China.
International journal of nanomedicine
|April 16, 2025
概括
这项研究开发了一种新的水凝,用于输送易布洛芬 (IBU),用于糖尿病伤口愈合. 该系统有效降低炎症,促进组织再生,在14天内加速伤口关闭.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 伤口治愈研究研究 伤口治愈研究
背景情况:
- 糖尿病伤口表现出过度的炎症,延长愈合和增加并发症风险.
- 目前的治疗方法面临着挑战,因为药物溶解性差和半衰期短,需要先进的输送系统.
- 调节炎症对于加速糖尿病伤口愈合和改善患者生活质量至关重要.
研究的目的:
- 开发一种多重交叉连接的复合水凝,用于控制和持续释放布洛芬 (IBU).
- 解决IBU在糖尿病伤口管理中的水溶性差和短半衰期的局限性.
- 创建一个可注射的水凝系统,通过减少炎症和刺激组织再生,促进糖尿病伤口愈合.
主要方法:
- 在现场使用氧化酸盐 (OSA),甲基合凝 (GelMA) 和易布洛芬/氨基基基基改性β-环极含复合物 (IBU/CD-NH2) 合成了一种多重交联复合水凝.
- 交叉连接策略包括离子交叉连接,光交叉连接和希夫基反应.
- 评估了水凝的物理化学特性,生物相容性,可注射性和药物释放动力学. 在体外和体内研究中评估了其在促进糖尿病伤口愈合方面的治疗效果.
主要成果:
- 优化的水凝配方表现出增强的机械强度,有利的生物相容性,可调性降解和可注射性.
- 该系统成功地解决了IBU溶解性和吸收问题,使药物释放得到控制和持续.
- 细胞和动物研究表明,水凝促进了血管生成,纤维细胞迁移,颗粒组织形成和表皮再生,在14天内显著加快了伤口关闭.
结论:
- 开发的水凝系统有效地抑制炎症,并通过控制IBU释放刺激组织再生.
- 这种创新方法为糖尿病伤口的管理提供了一个高度有效的策略.
- 水凝系统在加速糖尿病伤口愈合方面具有很强的临床应用潜力.
相关概念视频
01:30Modified-Release Drug Delivery Systems: Stimuli-Activated
177
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
177
01:26Oral Drug Delivery Systems: Continuous-Release Systems
308
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
308
01:11Oral Drug Delivery Systems: Delayed-Release Systems
222
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
222
01:28Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices
208
Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
208
01:21Intrauterine Drug Delivery Systems
168
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
168
01:31Diabetic Foot Ulcer
33
Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory...
33