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链接器决定的折叠和疏水相互作用解释了PROTAC细胞透性的重大差异

Vasanthanathan Poongavanam1, Stefan Peintner1, Yordanos Abeje1

  • 1Department of Chemistry - BMC, Uppsala University, Box 576, 75 123 Uppsala, Sweden.

ACS medicinal chemistry letters
|April 16, 2025
PubMed
概括

细胞透性需要PROTACs (蛋白质溶解向的嵌合体) 的极地表面积较低. 链接器化学决定了PROTAC的形状和细胞透,影响了药物开发.

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