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基于碎片发现类似药物LRH-1激动剂

Alisa Lang1, Niklas Ildefeld1, Felix F Lillich2

  • 1Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany.

ACS medicinal chemistry letters
|April 16, 2025
PubMed
概括

研究人员确定了具有改善药物样性质的新型肝受体同类1 (LRH-1) 激动剂. 这些化合物表现出强烈的激活功效和抗炎作用,为代谢和炎症疾病提供了潜在的潜力.

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