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Updated: May 13, 2025

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在固体瘤中治疗严重的细胞因子释放综合征的埃马帕卢马布:CAR-T:一个病例报告

Tyler Ruemmele1, Rodney Macedo2,3, Mark N Stein2

  • 1Division of Hematology/Oncology, New-York Presbyterian Hospital/Columbia University Irving Medical Center, New York, NY, United States.

Frontiers in oncology
|April 16, 2025
PubMed
概括

化学抗原受体T (CAR-T) 细胞疗法对固体瘤有希望,但严重的细胞因子释放综合征 (CRS) 是一个挑战. 在前列腺癌患者中,埃马帕卢马布成功治疗了耐火性CRS,保持了CAR-T的疗效.

关键词:
卡尔 (化学抗原受体) T 细胞嵌合式抗原受体 (CAR T)细胞因子释放综合征 (CRS)埃帕马卢马布拉姆 (Epapalumab) 是一个免疫效应细胞相关的HLH类综合征 (IEC-HS)干扰素玛 (IFNγ) 的作用.前列腺特异性抗原 (PSA)前列腺干细胞抗原 (PSCA)

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Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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