瘤微环境在HNSCC耐药性和向治疗中的作用
Zhaomeng Guo1, Kang Li1, Xiaotong Ren1
1Department of Otolaryngology, Longgang Otolaryngology hospital & Shenzhen Key Laboratory of Otolaryngology, Shenzhen Institute of Otolaryngology, Shenzhen, Guangdong, China.
Frontiers in immunology
|April 16, 2025
概括
由于治疗耐药性,头部和部状细胞癌 (HNSCC) 的预后不佳. 向瘤微环境 (TME) 为HNSCC管理提供了新的治疗策略.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
背景情况:
- 头部和部状细胞癌 (HNSCC) 的预后不利,主要是由于治疗耐药性.
- 癌细胞对各种治疗方法的抗性是瘤学中的一个重大挑战.
- 瘤微环境 (TME) 在HNSCC中显著影响瘤进展和治疗结果.
研究的目的:
- 提供HNSCC瘤微环境的全面审查.
- 阐明TME组件在HNSCC治疗耐药性的作用.
- 探索针对HNSCC的新型TME向治疗策略.
主要方法:
- 对HNSCC瘤微环境组件的文献综述.
- 分析免疫细胞 (TAMs,Tregs,MDSCs),CAFs,ECM和代谢重编程在HNSCC中的作用.
- 检查TME对化疗,放射治疗,向治疗和免疫治疗耐药性的影响.
主要成果:
- HNSCC TME包括各种非恶性成分,促进瘤生长,入侵和转移.
- 特定的TME成分,包括TAMs,Tregs,MDSCs,CAFs和改变的新陈代谢,有助于抵抗各种治疗方式.
- 在HNSCC中,TME关键调节化疗,放射治疗,向治疗和免疫治疗的疗效.
结论:
- HNSCC TME在治疗耐药性和疾病进展方面发挥着关键作用.
- 了解TME的组成和功能对于开发有效的HNSCC治疗至关重要.
- 准TME为克服治疗耐药性和改善HNSCC患者结果提供了一个有希望的途径.
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