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在多发性硬化症中的斑点内视网膜层.

Ori Zahavi1, Maria Nilsson1, Ali Manouchehrinia2

  • 1Unit of Optometry, Division of Eye and Vision, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.

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概括

多发性硬化症 (MS) 导致视网膜内层变薄,特别是神经纤维层 (NFL),这可能表明全球缩. 光学连贯断层扫描 (OCT) 与健康对照组相比,在MS患者中揭示了这些结构变化.

关键词:
结节细胞内部的形层是形层.视网膜内层的内层是视网膜的内层.多发性硬化症多发性硬化症光学连贯性断层扫描技术视网膜神经纤维层是一种神经纤维层.

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科学领域:

  • 眼科医生 眼科 眼科
  • 神经科学是一个神经科学.
  • 医疗成像医学成像

背景情况:

  • 多发性硬化症 (MS) 是一种慢性神经系统疾病.
  • 视网膜层变薄是MS中神经退行症的潜在指标.

研究的目的:

  • 在MS患者中使用光学连贯性断层扫描 (OCT) 评估视网膜内层的结构变化.
  • 确定最受影响的视网膜层,并比较MS亚型 (PP,RR,SP) 与健康对照 (HC) 之间的变化.

主要方法:

  • 对来自507名多发性硬化和183名高血压患者的OCT数据进行了回顾性分析.
  • 测量斑点神经纤维层 (NFL),状细胞层 (GCL),内状层 (IPL) 和内核层 (INL) 的厚度.
  • 在MS亚型和HC之间比较层厚,控制年龄,性别和视神经炎 (ON) 史.

主要成果:

  • 所有多发性硬化小组都显示出较薄的NFL,特别是在下部,上部和鼻腔部门 (3-20%的减少).
  • 观察到GCL稀释,最显著的是SP亚组的内鼻部门 (27.8%的减少).
  • 在所有MS小组中,IPL厚度降低;RR患者在内部部门显示INL厚度增加.

结论:

  • 黄斑区域是监测多发性硬化症神经退行的一个可行的区域.
  • 斑点NFL稀疏与MS有很强的相关性,可能作为全球缩的标志物.
  • IPL和GCL的稀释模式是相似的,表明了联合测量潜力.