牛皮管理中的感染风险和疫苗接种:对生物治疗的考虑
Laura Mateu-Arrom1, Lluis Puig1
1Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Universitat Autònoma de Barcelona, Barcelona, Spain.
Psoriasis (Auckland, N.Z.)
|April 16, 2025
概括
牛皮的生物治疗可以通过阻断免疫路径来增加感染风险. 需要更新的指导方针来个性化预防策略,包括查和疫苗接种,基于特定的药物机制.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 针对牛皮的Th1和Th17途径的生物疗法调节了免疫反应.
- 阻止这些途径对抗感染至关重要,可能会增加对病原体的敏感性.
- 瘤坏死因子 (TNF) 抑制剂与潜在结核病和乙型肝炎重新激活的风险增加有关.
研究的目的:
- 审查牛皮患者生物治疗的关键考虑因素,重点关注感染风险.
- 为预防,查和管理与生物制剂相关的感染提供当前建议.
- 突出需要修订的指导方针,考虑到特定的药物机制和临床证据.
主要方法:
- 关于牛皮的生物治疗方法和相关感染风险的现有文献的叙述性综述.
- 对目前预防感染的建议进行分析,包括疫苗接种和查方案.
- 评估与各种生物类 (例如TNF,IL-17,IL-23抑制剂) 相关的不同感染风险.
主要成果:
- 针对Th1和Th17通路的生物药物具有潜在的感染风险.
- 与TNF抑制剂相比,IL-17和IL-23抑制剂可能具有较低的感染风险.
- 建议在治疗前对所有开始生物治疗的患者进行感染查.
- 建议采用标准的疫苗接种计划,不包括大多数活体减弱疫苗.
结论:
- 目前的生物药物感染管理指南需要修订,以反映特定药物机制.
- 个性化治疗方法是必不可少的,考虑到患者的感染风险概况.
- 需要进行进一步的研究,以完善在牛皮患者接种疫苗和感染查的建议.
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