lncRNAs和circRNAs:儿科脑髓母细胞瘤病理学的新兴参与者
Ozal Beylerli1, Elmar Musaev2, Tatiana Ilyasova3
1Central research laboratory, Bashkir State Medical University, Ufa, 3 Lenin Street, 450008, Russia.
Current medicinal chemistry
|April 16, 2025
概括
非编码RNAs (ncRNAs) 是儿科骨髓母细胞瘤的关键参与者,影响瘤的生长和扩散. 针对这些ncRNAs为患有脑瘤的儿童提供了有希望的新诊断和治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 脑髓母细胞瘤是一种具有挑战性的治疗结果的侵袭性儿科脑瘤.
- 目前的疗法由于毒性和耐药性而面临局限性.
- 非编码RNAs (ncRNAs) 越来越多地被认为是它们在癌症发展中的作用.
研究的目的:
- 审查长非编码RNAs (lncRNAs) 和圆形RNAs (circRNAs) 在儿科骨髓母细胞瘤中的作用.
- 探索ncRNAs作为诊断/预后生物标志物.
- 讨论针对ncRNA的治疗策略和挑战.
主要方法:
- 文献综述侧重于脑髓母细胞瘤中的ncRNAs.
- 对特定的lncRNAs (例如HOTAIR,TP73-AS1) 和circRNAs (例如circ-SKA3,circ_63706) 的分析.
- 检查ncRNA参与致癌过程和子组特异性作用的研究 (SHH,第三组).
主要成果:
- ncRNAs显著调节基因表达,影响脑髓母细胞瘤中的增殖,亡和转移.
- 特定的ncRNA显示出在脑脊液 (CSF) 中可检测到的生物标志物的潜力.
- 新兴的疗法,如反感性寡核酸和基于CRISPR的编辑,准致癌性ncRNAs.
结论:
- ncRNAs是儿科骨髓母细胞瘤病变发生的关键调节者.
- 基于ncRNA的诊断和治疗具有改善患者结果的革命性潜力.
- 需要进一步的研究,以克服临床翻译的交付和特异性的挑战.
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