预测和SHAP分析整合形态和血液动力学参数,用于流量转换器治疗后未破裂的内动脉瘤闭塞
Hongchen Zhang1, Chuanhao Lu1, Zhen Hu2
1Department of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
CNS neuroscience & therapeutics
|April 16, 2025
概括
这项研究开发了一种预测模型,用于在流量转移器 (FD) 治疗后未破裂的内动脉瘤 (UIA) 阻塞. 该模型整合了形态和血液动力学因素,有助于个性化患者管理和降低破裂风险.
科学领域:
- 神经外科 神经外科
- 生物医学工程 生物医学工程
- 医疗成像医学成像
背景情况:
- 大多数未破裂的内动脉瘤 (UIA) 用流量转移器 (FD) 治疗具有良好的结果.
- 然而,一些UIA仍未被封闭,造成持续的破裂风险.
- 个性化术后管理对于这些病例至关重要.
研究的目的:
- 开发FD治疗后UIA封闭的预测模型.
- 整合形态和血液动力学参数,以提高预测.
- 支持个性化的术后管理策略.
主要方法:
- 从单个UIA患者的患者收集的数据,这些患者接受了独立的FD治疗.
- 利用形态和计算流体动力学 (CFD) 的3D模型进行血液动力学分析.
- 采用机器学习算法 (逻辑回归,随机森林,XGBoost,KNN) 和SHAP分析用于模型开发和特征重要性.
主要成果:
- 使用后勤回归开发了一个预测模型,实现了AUC> 0.75.
- 关键预测因素包括随访时间,动脉瘤破裂率,阻塞率和父动脉壁剪压 (WSS) 变化.
- 母动脉WSS的变化是早期和准确的阻塞预测最重要的预测因素.
结论:
- 开发了一个强大的模型,预测FD后治疗UIA阻塞.
- 该模型整合了关键的形态和血液动力学参数.
- 这种工具可以帮助临床决策,以优化治疗策略.
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