保持大脑健康:身体活动和健身对老化大脑的影响-英国生物库研究
Hanna Hoogen1,2, Bruno Hebling Vieira1, Nicolas Langer1
1Department of Psychology, University of Zurich, Zurich, Switzerland.
The European journal of neuroscience
|April 16, 2025
概括
加速度计测量身体活动 (PA) 和健身指标,如握力和较低的BMI,减缓大脑衰老. 适应性部分解释了PA PA.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 预防医学 预防医学
背景情况:
- 衰老与增加的身体和神经系统疾病有关.
- 大脑结构和功能变化是与年龄相关衰退的关键.
- 识别对大脑健康的保护因素至关重要.
研究的目的:
- 为了研究加速仪测量身体活动 (PA) 和身体健康对BrainAGE的影响,这是大脑衰老的标志物.
- 分析PA,健身和大脑衰老之间的关系.
- 探索健身对PA-大脑衰老关系的调解作用.
主要方法:
- 从21,442名英国生物库参与者中使用神经成像特征训练了一个BrainAGE模型.
- 将BrainAGE模型应用于10,874名参与者的独立样本.
- 评估加速仪测量PA,自我报告的PA,手握强度,BMI,透气血压 (DBP) 和静止心率.
主要成果:
- 加速度计测量中等强度的PA与减缓大脑衰老 (负BrainAGE) 有关.
- 较高的握力和较低的BMI,DBP和静止心率与较慢的大脑衰老有关.
- 健身指标独立地影响了BrainAGE,并部分调解了PA-BrainAGE关系 (BMI,DBP,静止心率).
结论:
- 用加速度计测量PA,而不是自我报告,与大脑衰老缓慢有关.
- 身体健康在减缓大脑衰老方面发挥着重要作用,独立于PA.
- 动力压力和健身之间的相互作用对于保持老化中的大脑健康至关重要.
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