纯母乳养与婴儿的肠道微生物组成熟有关,根据分娩方式
Nathalia F Naspolini1, Paulo A Schüroff2, Pedro A R Vanzele3
1Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
Gut microbes
|April 16, 2025
概括
纯母乳养 (EBF) 促进婴儿肠道微生物群的健康,影响其发育和成熟. EBF影响微生物基因和通路,导致微生物组年龄更接近婴儿的时间年龄.
科学领域:
- 微生物学 微生物学
- 儿科 儿科 儿科
- 营养科学 营养科学
背景情况:
- 纯母乳养 (EBF) 对婴儿肠道微生物组的发展至关重要.
- 关于EBF在恢复扰乱的婴儿微生物组中的作用的研究有限.
研究的目的:
- 研究EBF对婴儿肠道微生物组组合和成熟的影响.
- 确定与EBF相关的微生物和功能决定因素.
主要方法:
- 来自525名巴西婴儿 (3-9个月) 的肠道微生物组的整个元基因组测序.
- 微生物分类学,功能和代谢途径的分析.
- 机器学习方法来预测EBF状态.
主要成果:
- EBF显著改变了微生物基因的丰富性,分类学和功能.
- 特定的途径 (碳水化合物,脂质,细胞结构) 是由EBF调节的,受传递方式的影响.
- EBF导致微生物组年龄较小 (微生物组成熟指数较低).
- 大肠杆菌 (Escherichia coli),球菌 (Ruminococcus gnavus),新生儿菌 (Clostridium neonatale) 和特定的代谢途径预测了EBF状态.
结论:
- EBF塑造了早期婴儿肠道微生物组的组成和功能.
- EBF促进了微生物组成熟状态,更接近婴儿的时间年龄.
- 传递方式影响EBF的微生物组效应.
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