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Updated: May 13, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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基于DNA框架的色素向化马:细胞内ATP促进的细胞外蛋白降解

Yujun Ning1, Bin Li1, Weishuai Chen1

  • 1Department of Chemistry, Shanghai Stomatological Hospital, State Key Laboratory of Molecular Engineering of Polymers and Institute of Biomedical Sciences, Fudan University, Shanghai 200433, People's Republic of China.

ACS nano
|April 16, 2025
PubMed
概括

这项研究引入了基于四面体DNA框架的化体向仿真体 (TDF-LYTACs),用于向蛋白质降解. 这些TDF-LYTACs将细胞外蛋白质降解与细胞内腺三酸盐 (ATP) 水平联系起来.

关键词:
通过ATP传感和成像来进行检测.细胞外蛋白质是细胞外蛋白质.准的目标是木乃伊.有针对性的降解降解目标.四面体的DNA框架

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