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Updated: May 13, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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Published on: May 9, 2025

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在体外结构-活动关系稳定性研究使用生物矩阵和核酶的反意义寡核酸治疗方法

Jelena Lovrić1, Jingjing Yan1, XueQing Li1

  • 1DMPK, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.

Pharmacology research & perspectives
|April 16, 2025
PubMed
概括

反感性寡核酸 (ASO) 的稳定性对于药物开发至关重要. 这项研究开发了体外测试,以预测ASO代谢,发现骨干化学和序列影响稳定性,帮助选择最佳候选药物.

关键词:
在ASO的基础上,ASO是ASO.代谢稳定性 代谢稳定性核酶核酶是什么意思

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