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相关概念视频

Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

377
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
377

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Updated: May 13, 2025

Microglia as a Surrogate Biosensor to Determine Nanoparticle Neurotoxicity
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纳米粒子诱导的神经毒性

Divya Bajpai Tripathy1, Subhalaxmi Pradhan1, Anjali Gupta1

  • 1Department of Chemistry, School of Basic Sciences, Galgotias University, Greater Noida, India.

Nanotoxicology
|April 16, 2025
PubMed
概括
此摘要是机器生成的。

本综述探讨了包括白银和二氧化在内的各种纳米粒子如何引起神经毒性. 了解纳米粒子毒性对于安全的纳米技术开发和应用至关重要.

关键词:
纳米颗粒 纳米颗粒血脑屏障是什么意思神经炎症是一种神经炎症.神经毒性的作用.氧化应激是一种氧化应激.

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科学领域:

  • 纳米技术 纳米技术
  • 神经科学是一个神经科学.
  • 毒理学 毒理学 毒理学

背景情况:

  • 纳米粒子 (NPs) 穿透诸如血脑屏障 (BBB) 等生物屏障,引发了人们对神经毒性的担忧.
  • 包括金属氧化物和碳基材料在内的各种NP正在对其潜在的神经效应进行审查.

研究的目的:

  • 审查各种纳米粒子诱导的神经毒性机制.
  • 突出影响NP神经毒性的因素,并讨论预防策略.

主要方法:

  • 关于纳米粒子神经毒性的体外和体内研究的文献综述.
  • 对参与NP诱导的神经元损伤的信号通路的分析.

主要成果:

  • 纳米粒子可以通过氧化应激,神经炎症和线粒体功能障碍诱导神经毒性.
  • 毒性取决于NP特征 (大小,表面) 和暴露因素 (剂量,接受者的健康状况).

结论:

  • 全面的安全评估对于纳米粒子的安全使用至关重要.
  • 表面修饰和抗氧化剂治疗在缓解NP神经毒性方面表现有前途.