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Updated: May 13, 2025

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A Free-breathing fMRI Method to Study Human Olfactory Function
Published on: July 30, 2017
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轻度认知障碍和主观认知衰退中的嗅觉相关大脑区域的结构异常 个人
Lujiang Zhan1, Guanxiong Tan1, Jia Dong1
1Department of Radiology, Third People's Hospital of Honghe Hani and Yi Autonomous Prefecture, Gejiu, China.
Journal of geriatric psychiatry and neurology
|April 16, 2025
概括
嗅觉障碍和大脑区域缩随着认知能力下降而恶化. 在主观认知障碍 (SCD) 中,脑内皮层和海马灰质的减少与嗅觉丧失有关.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 医疗成像医学成像
背景情况:
- 嗅觉障碍可能在主观认知障碍 (SCD) 和阿尔茨海默氏病 (AD) 的认知衰退之前发生.
- 在SCD中嗅觉障碍与神经解剖学联系尚未完全理解.
研究的目的:
- 研究健康对照 (HC),SCD和轻度认知障碍 (MCI) 个体的嗅觉功能和大脑结构之间的关系.
- 为了确定与SCD中嗅觉障碍相关的特定嗅觉相关的大脑区域.
主要方法:
- 120名老年人 (25 HC,45 SCD,50 MCI) 接受了嗅觉评估 (嗅探棒的气味识别测试) 和结构MRI.
- 兴趣区域 (ROI) 分析侧重于8个与嗅觉相关的大脑区域的灰质体积 (GMV).
主要成果:
- 从HC到SCD到MCI组观察到嗅觉区域的渐进GMV减少和恶化的嗅觉障碍.
- 在HC中,嗅觉障碍与减少的内腔皮层GMV相关.
- 在SCD中,嗅觉障碍与内皮层和海马体GMV的减少有关.
- 在MCI中,嗅觉障碍与皮质皮质,杏仁体,内腔皮质,轨道前皮质,海马体和副海马体的GMV下降有关.
结论:
- 嗅觉区域的大脑缩和嗅觉功能障碍随着认知能力下降的严重程度 (HC,SCD,MCI) 的增加而增加.
- 耳鼻皮层和海马体是关键的嗅觉相关区域,与SCD的嗅觉障碍有关.
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