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治疗中风患者的治疗结果和治疗时间的性别差异,这些患者接受了基治疗
Marion Yger1,2,3, Edouard Januel4,5, Thomas Checkouri1,2
1AP-HP, Urgences Cérébro-Vasculaires, Hôpital Pitié-Salpêtrière, Sorbonne Université, Paris, France.
European stroke journal
|April 16, 2025
概括
妇女和男性在用丁氏甲治疗缺血性中风后的结果相似. 然而,女性的症状性内出血 (symptomatic intracranial hemorrhages,SICH) 较少,未知中风发病率更高.
科学领域:
- 神经学 神经学
- 脑卒中医学 脑卒中医学
- 医学中的性别差异.
背景情况:
- 了解基于性别的差异对于优化女性中风护理至关重要.
- 以前的研究表明,男性和女性中风预后和治疗结果可能存在差异.
研究的目的:
- 为了评估基于性别的预后差异,症状性内出血 (sICH) 率,以及用tenecteplase治疗的缺血性中风患者的过程时间.
- 为了确定可能影响中风结果的性别特异性因素.
主要方法:
- 进行了对法国中风注册 (2015-2021) 中的特内克治疗的回顾性分析.
- 用多变量逻辑回归评估了3个月神经结果,sICH发生和过程时间的性别差异.
- 包括1339名患者 (684名女性,655名男性) 接受了甲,其中873人接受了血栓切除术.
主要成果:
- 在女性和男性之间没有观察到3个月良好神经结果的显著差异 (aOR = 0.85 [0.63-1.13]).
- 妇女在使用基剂后患病率明显较低 (aOR = 0.35 [0.18-0.69]).
- 女性更有可能患有未知发病的中风 (aOR = 1.44 [1.07-1.95]),但一旦激活了中风代码,工作流量指标就类似了.
结论:
- 这项研究发现,在治疗缺血性中风后3个月的神经结果中没有显著的性别差异.
- 妇女在给药后表现出较低的SICH发病率.
- 虽然工作流量指标是可比的,但女性中风发病率较高,不知发病原因,需要进一步调查.
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